Induction of antinuclear antibodies by ultraviolet irradiation.

Induction of antinuclear antibodies by ultraviolet irradiation.

Ultraviolet (UV) irradiation or exposure to sunlight are well known but poorly understood predisposing factors of systemic lupus erythematosus (SLE) (Dubois, 1966; Freeman, Knox, and Owens, 1969). It appears from the published literature, that little attention has been paid to what actually occurs when apparently healthy individuals are exposed to UV irradiation. On a molecular level, UV irradi...

Antinuclear Antibodies

knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...

Induction of Antinuclear Antibodies by De Novo Autoimmune Hepatitis Regulates Alloimmune Responses in Rat Liver Transplantation

Concanavalin A (Con A) is a lectin originating from the jack-bean and well known for its ability to stimulate T cells and induce autoimmune hepatitis. We previously demonstrated the induction of immunosuppressive antinuclear autoantibody in the course of Con A-induced transient autoimmune hepatitis. This study aimed to clarify the effects of Con A-induced hepatitis on liver allograft rejection ...

Inactivation of Airborne Viruses by Ultraviolet Irradiation.

Aerosolized viruses were passed through a high-intensity ultraviolet (UV) cell. This cell consisted of a long cylindrical aluminum tube [diameter, 7 in. (17.7 cm); length, 36 in. (91.4 cm)] with a highly reflective inner surface and a longitudinally extending helical baffle system which directed airborne particles in close proximity to a centrally located UV lamp. After having been passed throu...

Antinuclear antibodies in systemic sclerosis